Myosteatosis in Oeso-gastric Cancer: Clinical Impacts

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The aim of this project is to study the presence of cancer-associated adipocytes in oesogastric cancers and their possible links with myosteatosis. This research project has a retrospective component, the aim of which is to analyse the body component based on imaging in patients with oesogastric neoplasia in order to determine the incidence of myosteatosis and to study the relationship with oncological and prognostic data. The second part of the project is prospective and will collect biological material (skeletal muscle, adipose tissue, tumour, blood) for histological, molecular and genomic analyses and will analyse muscle function in patients with oesogastric cancer. It will address the role of adipocytes in the tumour microenvironment of oesogastric cancer, focusing on their interactions with the observed muscle myosteatosis and prognosis. In the future, it will help to identify signalling pathways, targets and patients who could benefit from appropriate treatment.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients with cancer of the oesophagus, oeso-gastric junction or stomach

• Treatment and estimated survival of more than 3 months

• Signed informed consent

• \> 18 years of age

Locations
Other Locations
Belgium
Cliniques universitaires Saint-Luc
RECRUITING
Brussels
Contact Information
Primary
Yannick Deswysen, MD
yannick.deswysen@saintluc.uclouvain.be
00327642213
Backup
Nicolas Lanthier, PhD
nicolas.lanthier@saintluc.uclouvain.be
00327642822
Time Frame
Start Date: 2024-05-01
Estimated Completion Date: 2026-05-31
Participants
Target number of participants: 50
Treatments
Other: Surgical patients
Patients undergoing surgery
Other: Non surgical patients
Patients not undergoing surgery
Related Therapeutic Areas
Sponsors
Leads: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

This content was sourced from clinicaltrials.gov